Videos from the Webinar with Dr. Serge Verstovsek on the Future of MPN Treatment

📅 Originally aired: May 29, 2025
🎙 Hosted by the Global MPN Scientific Foundation
🧪 Featuring: Dr. Serge Verstovsek, world-leading MPN researcher

The Global MPN Scientific Foundation, in collaboration with Kartos Therapeutics, recently hosted an exclusive webinar with Dr. Serge Verstovsek, offering a unique window into the POIESIS clinical trial and the future of Myeloproliferative Neoplasm (MPN) treatment.

Dr. Verstovsek shared cutting-edge updates on the development of Navtemadlin, a promising new therapy for Myelofibrosis, and answered key questions from the community about clinical research and access to innovative treatments.

This session provided invaluable information for both patients and professionals seeking to stay informed about the latest in MPN care.

PART 1 – A New Era: Navtemadlin and the Therapeutic Approach

Dr. Verstovsek introduced Navtemadlin, a new oral therapy designed to restore P53 activity and drive cancer cell death selectively. This section explained how the drug works, its targeted action in MPNs, and the biological rationale behind its use.

https://vimeo.com/1089996279/642db1d0fe?share=copy 

PART 2 – What is POIESIS? Understanding the Trial

In this part, the focus was on the POIESIS Phase 3 trial, evaluating Navtemadlin in transfusion-dependent patients with Myelofibrosis. Dr. Verstovsek explained eligibility criteria, goals of the study, endpoints, and what patients can expect from participation.

https://vimeo.com/1094655907/678f2410fa?share=copy 

PART 3 – Q&A: What Patients Need to Know

The session ended with a round of insightful questions from the live audience. Topics included access to clinical trials, potential side effects, and how patients can find out if they are eligible. Dr. Verstovsek addressed these with clarity and reassurance.

https://vimeo.com/1089996418/0cbf9f7438?share=copy 

Why this matters

Clinical research is moving fast. POIESIS represents a step forward in developing treatments that go beyond symptom control, aiming for disease modification and better quality of life.

At the Global MPN Scientific Foundation, we believe in providing access to trustworthy, expert-led information. Sessions like this empower the community and build a bridge between science and real-life experience.

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Together, we move forward.